Constitutive Role for IRE1α-XBP1 Signaling Pathway in the Insulin-Mediated Hepatic Lipogenic Program

IREα/XBP1a pathway is linked with the insulin-dependent hepatic lipogenesis. The role of the IRE1α-X-box-binding protein 1 (XBP1) pathway in the insulin-mediated hepatic lipogenic program and associated mechanisms were investigated in this study. We observed that phosphorylation of IRE1α (an upstrea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2011-06, Vol.152 (6), p.2247-2255
Hauptverfasser:	Ning, Jie, Hong, Tao, Ward, Adam, Pi, Jingbo, Liu, Zhenqi, Liu, Hui-Yu, Cao, Wenhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Chromatin Diabetes mellitus DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endoribonucleases - genetics Endoribonucleases - metabolism Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty-acid synthase Female Fundamental and applied biological sciences. Psychology General Endocrinology Genes Hepatocytes Hepatocytes - metabolism High fat diet Humans Hyperinsulinemia Hyperinsulinism - genetics Hyperinsulinism - metabolism Immunoprecipitation Insulin Insulin - metabolism Insulin Resistance Lipogenesis Liver Liver - cytology Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred NOD Phosphorylation Promoter Regions, Genetic Protein biosynthesis Protein folding Protein synthesis Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Rapamycin Regulatory Factor X Transcription Factors Signal Transduction siRNA Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterol regulatory element-binding protein TOR protein Transcription Factors - genetics Transcription Factors - metabolism Vertebrates: endocrinology X-Box Binding Protein 1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!