DNA fragmentation during apoptosis is caused by frequent single-strand cuts

One of the hallmarks of apoptosis Is the digestion of genomlc DNA by an endonuclease, generating a ladder of small fragments of double-stranded DNA. We have examined the nature of the DNA breaks produced In mouse thymocytes triggered to undergo apoptosis by steroids or by stimulation of the T cell r...

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Veröffentlicht in:	Nucleic acids research 1993-09, Vol.21 (18), p.4206-4209
Hauptverfasser:	Peitsh, Manuel C., Muüller, Christian, Tschopp, Jü
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences CD3 Complex - physiology Cell physiology Cells, Cultured Computer Simulation Dexamethasone - pharmacology DNA Damage Electrophoresis, Agar Gel Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Signal Transduction
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