Nucleus accumbens facilitates nociception

We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. Howe...

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Veröffentlicht in:	Experimental neurology 2011-06, Vol.229 (2), p.502-506
Hauptverfasser:	Gear, Robert W., Levine, Jon D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analysis of Variance Anatomy Animals Biological and medical sciences Central nervous system delta Electrodes, Implanted Enkephalin, Ala-MePhe-Gly- - pharmacology Enkephalin, Ala-MePhe-Gly- - therapeutic use Fundamental and applied biological sciences. Psychology Glutamate Injections, Spinal Jaw opening reflex Kainate Lidocaine Lidocaine - pharmacology Male Medical sciences Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology Neurology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Nucleus Accumbens - physiopathology Opioids Pain Pain - drug therapy Pain - metabolism Pain - physiopathology Pain Measurement - drug effects Pain Perception - drug effects Pain Perception - physiology Rat Rats Rats, Sprague-Dawley Receptors, Opioid - metabolism Somatostatin - analogs & derivatives Somatostatin - pharmacology Spinal Cord - drug effects Spinal Cord - metabolism Vertebrates: nervous system and sense organs
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