Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats

Serotonin 1A receptor (5-HT 1AR) agonists reduce both l-DOPA- and D1 receptor (D1R) agonist-mediated dyskinesia, but their anti-dyskinetic mechanism of action is not fully understood. Given that 5-HT 1AR stimulation reduces glutamatergic neurotransmission in the dopamine-depleted striatum, 5-HT 1AR...

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Veröffentlicht in:	Experimental neurology 2011-06, Vol.229 (2), p.288-299
Hauptverfasser:	Dupre, Kristin B., Ostock, Corinne Y., Eskow Jaunarajs, Karen L., Button, Thomas, Savage, Lisa M., Wolf, William, Bishop, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 1A receptor 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Antiparkinson Agents - pharmacology Benserazide - pharmacology Benzazepines - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - metabolism D1 receptor Dopamine Agonists - pharmacology Dyskinesia Dyskinesia, Drug-Induced - metabolism Glutamate Glutamic Acid - metabolism Injuries of the nervous system and the skull. Diseases due to physical agents l-DOPA Levodopa - pharmacology Male Medical sciences Microdialysis Neurology Neurons - drug effects Neurons - metabolism Oxidopamine Parkinson Disease, Secondary - metabolism Parkinson's disease Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1A - metabolism Serotonin Receptor Agonists - pharmacology Traumas. Diseases due to physical agents
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