Notch Signaling Pathway Enhances Bone Morphogenetic Protein 2 (BMP2) Responsiveness of Msx2 Gene to Induce Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells

Vascular calcification is regulated in a process similar to bone formation. BMP2 (bone morphogenetic protein 2) is essential for osteoblastic differentiation of mesenchymal progenitor cells and thus has been implicated in the development of vascular calcification. Here we examined whether Notch sign...

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Veröffentlicht in:	The Journal of biological chemistry 2011-05, Vol.286 (21), p.19138-19148
Hauptverfasser:	Shimizu, Takehisa, Tanaka, Toru, Iso, Tatsuya, Matsui, Hiroki, Ooyama, Yoshiaki, Kawai-Kowase, Keiko, Arai, Masashi, Kurabayashi, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Bone Morphogenetic Protein (BMP) Bone Morphogenetic Protein 2 - genetics Bone Morphogenetic Protein 2 - metabolism Calcification Calcinosis - genetics Calcinosis - metabolism Calcinosis - pathology Cell Differentiation Cell Line Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Mice Molecular Bases of Disease Msx2 Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Notch Pathway Notch Receptor Osteoblasts - metabolism Osteoblasts - pathology Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Signal Transduction Transcription Regulation
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