A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions

The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS...

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Veröffentlicht in:	The Journal of biological chemistry 2011-05, Vol.286 (21), p.18664-18672
Hauptverfasser:	Furukawa, Yoshiaki, Kaneko, Kumi, Watanabe, Shoji, Yamanaka, Koji, Nukina, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism HEK293 Cells Humans Intranuclear Inclusion Bodies - chemistry Intranuclear Inclusion Bodies - genetics Intranuclear Inclusion Bodies - metabolism Models, Biological Neurodegeneration Protein Aggregation Protein Folding Protein Structure and Folding Protein-Protein Interactions Response Elements Sarcosine - analogs & derivatives Sarcosine - blood Solubility
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