Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8+ T cells in t...

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Veröffentlicht in:	Blood 2011-04, Vol.117 (17), p.4501-4510
Hauptverfasser:	Zhou, Qing, Munger, Meghan E., Veenstra, Rachelle G., Weigel, Brenda J., Hirashima, Mitsuomi, Munn, David H., Murphy, William J., Azuma, Miyuki, Anderson, Ana C., Kuchroo, Vijay K., Blazar, Bruce R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antigens, Surface - genetics Antigens, Surface - immunology Antigens, Surface - metabolism Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - immunology Apoptosis Regulatory Proteins - metabolism CD8-Positive T-Lymphocytes - immunology Galectins - genetics Galectins - immunology Galectins - metabolism Gene Expression - immunology Genes, Lethal Hepatitis A Virus Cellular Receptor 2 Immunobiology Immunophenotyping Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - therapy Liver - cytology Liver - immunology Mice Mice, Inbred C57BL Mice, Knockout Myeloid Neoplasia Phenotype Programmed Cell Death 1 Receptor Receptors, Virus - genetics Receptors, Virus - immunology Receptors, Virus - metabolism Signal Transduction - immunology
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