Effective Gene Silencing by Multilayered siRNA-Coated Gold Nanoparticles

Small interfering RNA (siRNA) has been widely proposed to treat various diseases by silencing genes, but its delivery remains a challenge. A well controlled assembly approach is applied to prepare a protease‐assisted nanodelivery system. Protease‐degradable poly‐L‐lysine (PLL) and siRNA are fabricat...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-02, Vol.7 (3), p.364-370
Hauptverfasser:	Lee, Seung Koo, Han, Myung Shin, Asokan, Subashini, Tung, Ching-Hsuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Assembly Coating effects Control systems delivery Gene Silencing Gold gold nanoparticles Lysine Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission multilayer siRNA Nanoparticles Nanotechnology poly-L-lysine Polylysine - chemistry Protease Ribonucleic acid RNA RNA, Small Interfering - genetics siRNA
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