RNF20 Inhibits TFIIS-Facilitated Transcriptional Elongation to Suppress Pro-oncogenic Gene Expression

hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth-promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin and are inefficiently transcrib...

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Veröffentlicht in:	Molecular cell 2011-05, Vol.42 (4), p.477-488
Hauptverfasser:	Shema, Efrat, Kim, Jaehoon, Roeder, Robert G., Oren, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	chromatin Chromatin - metabolism DNA-directed RNA polymerase gene expression gene expression regulation Gene Expression Regulation, Neoplastic genes HeLa Cells histones Histones - genetics Histones - metabolism Humans neoplasms Neoplasms - genetics Nuclear Proteins - metabolism RNA Polymerase II - metabolism transcription (genetics) Transcription Factors Transcription, Genetic Transcriptional Elongation Factors - metabolism ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism
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