Relaxation gating of the acetylcholine‐activated inward rectifier K+ current is mediated by intrinsic voltage sensitivity of the muscarinic receptor

Non‐technical summary Normal heart rate variability is critically dependent upon the G‐protein‐coupled, acetylcholine (ACh)‐activated inward rectifier K+ current, IKACh. A unique feature of IKACh is the so‐called ‘relaxation’ gating property that contributes to increased current at hyperpolarized m...

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Veröffentlicht in:	The Journal of physiology 2011-04, Vol.589 (7), p.1755-1767
Hauptverfasser:	Moreno‐Galindo, Eloy G., Sánchez‐Chapula, José A., Sachse, Frank B., Rodríguez‐Paredes, J. Alberto, Tristani‐Firouzi, Martin, Navarro‐Polanco, Ricardo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholine - pharmacology Animals Bee Venoms - pharmacology Cardiovascular Cats Heart rate In Vitro Techniques Ion Channel Gating - drug effects Markov Chains Membrane Potentials Models, Biological Muscarinic Agonists - pharmacology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Patch-Clamp Techniques Pilocarpine - pharmacology Potassium Channels, Inwardly Rectifying - antagonists & inhibitors Potassium Channels, Inwardly Rectifying - metabolism Protein Conformation Proteins Receptors, Muscarinic - chemistry Receptors, Muscarinic - metabolism Rodents
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