Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?

Non‐technical summary In some forms of incurable epilepsies, GABAergic interneurons, which physiologically mediate inhibition in the brain, are thought to mediate excitation. The presence of a specific form of electrical communication between these cells, which is mediated by structures called gap...

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Veröffentlicht in:	The Journal of physiology 2011-04, Vol.589 (7), p.1663-1680
Hauptverfasser:	Beaumont, Michael, Maccaferri, Gianmaria
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - toxicity Allosteric properties Animals Anticonvulsants - pharmacology Benzodiazepine Brain Carbenoxolone - pharmacology Connexins Connexins - deficiency Connexins - genetics Connexins - physiology Drugs Epilepsy Epilepsy - chemically induced Epilepsy - physiopathology Firing pattern gamma -Aminobutyric acid gamma -Aminobutyric acid A receptors gamma-Aminobutyric Acid - physiology Gap Junction delta-2 Protein Gap junctions Gap Junctions - drug effects Gap Junctions - physiology Hippocampus Hippocampus - physiology Hypotheses In Vitro Techniques Interneurons Interneurons - physiology Kinetics Mefloquine Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Models, Neurological Neuroscience Neurosteroids Patch-Clamp Techniques Pregnenolone - pharmacology pregnenolone sulfate Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Side effects
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