RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder Cancer

Harnessing RNA interference (RNAi) to silence aberrant gene expression is an emerging approach in cancer therapy. Selective inhibition of an overexpressed gene via RNAi requires a highly efficacious, target-specific short interfering RNA (siRNA) and a safe and efficient delivery system. We have deve...

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Veröffentlicht in:	Molecular therapy 2011-05, Vol.19 (5), p.928-935
Hauptverfasser:	Seth, Shaguna, Matsui, Yoshiyuki, Fosnaugh, Kathy, Liu, Yan, Vaish, Narendra, Adami, Roger, Harvie, Pierrot, Johns, Rachel, Severson, Gregory, Brown, Tod, Takagi, Akihide, Bell, Susan, Chen, Yan, Chen, Feng, Zhu, Tianying, Fam, Renata, Maciagiewicz, Iwona, Kwang, Erin, McCutcheon, Michael, Farber, Ken, Charmley, Patrick, Houston, Michael E, So, Alan, Templin, Michael V, Polisky, Barry
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravesical Animals Bladder cancer Blotting, Western Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cholesterol - administration & dosage Cholesterol Esters - administration & dosage Disease Models, Animal Female Gene Expression Humans Inhibitor of Apoptosis Proteins - genetics Liposomes - administration & dosage Mice Mice, Nude Original Phosphatidylethanolamines - administration & dosage Polo-Like Kinase 1 Polymerase Chain Reaction Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics RNA Interference RNA, Messenger - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use Survivin Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy
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