EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer

A small subset of patients with nonsmall cell lung cancer (NSCLC) harbors mutations in the epidermal growth factor receptor (EGFR) that predict unique sensitivity to EGFR tyrosine kinase inhibitors (TKIs). The characteristics and behavior of brain metastases (BMs) in these patients have not been wel...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2010-11, Vol.12 (11), p.1193-1199
Hauptverfasser:	Eichler, April F., Kahle, Kristopher T., Wang, Daphne L., Joshi, Victoria A., Willers, Henning, Engelman, Jeffrey A., Lynch, Thomas J., Sequist, Lecia V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - secondary Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Clinical Investigations Combined Modality Therapy DNA Mutational Analysis Female Genes, erbB-1 - genetics Humans Kaplan-Meier Estimate Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Male Middle Aged Mutation Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Staging Neurosurgical Procedures Proportional Hazards Models Protein Kinase Inhibitors - therapeutic use Radiotherapy Treatment Outcome
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