Oxidized LDL immune complexes stimulate collagen IV production in mesangial cells via Fc gamma receptors I and III

Abstract Diabetic nephropathy is characterized by progressive mesangial expansion. Although we have reported that circulating oxidized LDL-containing immune complexes (oxLDL-IC) are associated with abnormal levels of albuminuria, the underlying mechanisms have not been investigated. In this study, w...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2011-06, Vol.139 (3), p.258-266
Hauptverfasser:	Abdelsamie, Souzan A, Li, Yanchun, Huang, Yan, Lee, Mi-Hye, Klein, Richard L, Virella, Gabriel, Lopes-Virella, Maria F
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antigen-Antibody Complex - immunology Biological and medical sciences Collagen Collagen Type IV - biosynthesis Collagen Type IV - immunology Diabetic Nephropathies - immunology Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - immunology Humans Immune complexes Immunoblotting Lipoproteins, LDL - immunology Low-density lipoprotein Mesangial cells Mesangial Cells - drug effects Mesangial Cells - immunology Mesangial Cells - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - immunology Nephropathy Protein Kinase Inhibitors - pharmacology Receptors, IgG - genetics Receptors, IgG - immunology Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - genetics
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