Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes

Interferon regularory factor 1 (IRF-1) is a DNA-bindlng factor which recognizes regulatory elements In the promoters of Interferon (IFN)-β and some IFN-Inducible genes. We observed that expression of transfected murlne IRF-1 In different mammalian cell lines leads to down-regulation or stop of proli...

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Veröffentlicht in:	Nucleic acids research 1993-06, Vol.21 (12), p.2881-2889
Hauptverfasser:	Kirchhoff, Sabine, Schaper, Fred, Hauser, Hansjörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell cycle, cell proliferation Cell Division - genetics Cell Line Cell physiology DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Gene Expression Humans Interferon Regulatory Factor-1 Interferon-beta - genetics Mice Molecular and cellular biology Phosphoproteins - genetics Phosphoproteins - physiology Receptors, Estrogen - genetics Recombinant Fusion Proteins - metabolism Transcription Factors - physiology Transcriptional Activation Transfection
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