A miniaturized 1536-well format gamma-secretase assay

gamma-Secretase is an aspartyl protease that cleaves multiple substrates including the amyloid precursor protein (APP) and the Notch proteins. Abnormal proteolysis of APP is involved in the pathogenesis of Alzheimer's disease (AD) and overactive Notch signaling plays an oncogenic role in a vari...

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Veröffentlicht in:	Assay and drug development technologies 2009-10, Vol.7 (5), p.461-470
Hauptverfasser:	Shelton, Christopher C, Tian, Yuan, Shum, David, Radu, Constantin, Djaballah, Hakim, Li, Yue-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Precursor Protein Secretases - analysis Amyloid Precursor Protein Secretases - metabolism Automation Biological assay Cost-Benefit Analysis Dose-Response Relationship, Drug Drug Discovery Drug Evaluation, Preclinical - instrumentation Drug Evaluation, Preclinical - methods Drug therapy Health aspects HeLa Cells Humans Indicators and Reagents Luminescence Miniaturization Original Physiological aspects Proteases
Online-Zugang:	Volltext
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