Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene

Recent cloning of a cDNA (UNG15) encoding human uracil-DNA glycosylase (UDG), indicated that the gene product of Mr = 33,800 contains an N-terminal sequence of 77 amino acids not present in the presumed mature form of Mr= 25,800. This led to the hypothesis that the N-termlnal sequence might be invol...

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Veröffentlicht in:	Nucleic acids research 1993-06, Vol.21 (11), p.2579-2584
Hauptverfasser:	Slupphaug, Geir, Markussen, Finn-Hugo, Olosen, Lisbeth C., Aasland, Rein, Aarsæther, Niels, Bakke, Oddmund, Krokan, Hans E., Helland, Dag E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry antibodies Biological and medical sciences cDNA Cell Nucleus - enzymology Chromatography, DEAE-Cellulose Chromatography, Gel Chromatography, Ion Exchange Cytosol - enzymology DNA Glycosylases Electrophoresis, Polyacrylamide Gel Enzymes and enzyme inhibitors Escherichia coli - enzymology Escherichia coli - genetics expression Fundamental and applied biological sciences. Psychology genes HeLa Cells Humans Hydrolases Immune Sera Isoenzymes - genetics Isoenzymes - isolation & purification Isoenzymes - metabolism Kinetics man mitochondria Mitochondria - enzymology Molecular Sequence Data N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - isolation & purification N-Glycosyl Hydrolases - metabolism nuclei Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Sequence Homology, Amino Acid Uracil-DNA Glycosidase uracil-DNA glycosylase
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