Circadian disruption and SCN control of energy metabolism
In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not on...
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| Veröffentlicht in: | FEBS letters 2011-05, Vol.585 (10), p.1412-1426 |
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| creator | Kalsbeek, Andries Scheer, Frank A. Perreau-Lenz, Stephanie La Fleur, Susanne E. Yi, Chun-Xia Fliers, Eric Buijs, Ruud M. |
| description | In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society. |
| doi_str_mv | 10.1016/j.febslet.2011.03.021 |
| format | Article |
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The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2011.03.021</identifier><identifier>PMID: 21414317</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>ACTH ; ad libitum ; Adipose Tissue - metabolism ; adrenocorticotrophic hormone ; Animals ; ANS ; Autonomic nervous system ; Autonomic Nervous System - metabolism ; Autonomic Nervous System - physiology ; biological clocks ; Bmal ; brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT) like ; cardiovascular system ; cerebrospinal fluid ; circadian locomotor output cycles kaput ; Circadian Rhythm - physiology ; CLOCK ; corticotrophin-releasing hormone ; CRH ; CRY ; cryptochrome ; CSF ; DMH ; dorsomedial nucleus of the hypothalamus ; energy ; energy metabolism ; Energy Metabolism - physiology ; FFA ; forced desynchrony ; free fatty acid ; GABA ; Gamma amino butyric acid ; Glucose ; GnRH ; gonadotropin-releasing hormone ; high energy foods ; hormone sensitive lipase ; Hormones - metabolism ; HPA ; HSL ; Humans ; hypothalamo-pituitary-adrenal ; Hypothalamus ; IML ; intermediolateral column of the spinal cord ; L/D ; light/dark ; lipoprotein lipase ; Liver ; LPL ; medial preoptic area ; Melatonin ; messenger RNA ; MPOA ; mRNA ; neuropeptide FF ; neuropeptide Y ; NPFF ; NPY ; Orexin ; PACAP ; paraventricular nucleus of the hypothalamus ; pePVN ; Per ; period ; periventricular nucleus of the hypothalamus ; physical activity ; pituitary adenylcyclase activating peptide ; PVN ; rate of (glucose) appearance ; restricted feeding ; SCN ; SHR ; society ; SON ; spontaneously hypertensive rat ; subparaventricular nucleus of the hypothalamus ; subPVN ; suprachiasmatic nuclei ; Suprachiasmatic Nucleus - metabolism ; Suprachiasmatic Nucleus - physiology ; supraoptic nuclei ; thyrotropin-releasing hormone ; TRH ; tyrosine hydroxylase ; vasoactive intestinal peptide ; ventromedial nucleus of the hypothalamus ; VIP ; VMH</subject><ispartof>FEBS letters, 2011-05, Vol.585 (10), p.1412-1426</ispartof><rights>2011 Federation of European Biochemical Societies</rights><rights>FEBS Letters 585 (2011) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><rights>2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6628-d1970a1c55d0ab79175803a9dcd48ce40bf9499262092260355ef3495c070ca43</citedby><cites>FETCH-LOGICAL-c6628-d1970a1c55d0ab79175803a9dcd48ce40bf9499262092260355ef3495c070ca43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2011.03.021$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579311001748$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21414317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalsbeek, Andries</creatorcontrib><creatorcontrib>Scheer, Frank A.</creatorcontrib><creatorcontrib>Perreau-Lenz, Stephanie</creatorcontrib><creatorcontrib>La Fleur, Susanne E.</creatorcontrib><creatorcontrib>Yi, Chun-Xia</creatorcontrib><creatorcontrib>Fliers, Eric</creatorcontrib><creatorcontrib>Buijs, Ruud M.</creatorcontrib><title>Circadian disruption and SCN control of energy metabolism</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society.</description><subject>ACTH</subject><subject>ad libitum</subject><subject>Adipose Tissue - metabolism</subject><subject>adrenocorticotrophic hormone</subject><subject>Animals</subject><subject>ANS</subject><subject>Autonomic nervous system</subject><subject>Autonomic Nervous System - metabolism</subject><subject>Autonomic Nervous System - physiology</subject><subject>biological clocks</subject><subject>Bmal</subject><subject>brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT) like</subject><subject>cardiovascular system</subject><subject>cerebrospinal fluid</subject><subject>circadian locomotor output cycles kaput</subject><subject>Circadian Rhythm - physiology</subject><subject>CLOCK</subject><subject>corticotrophin-releasing hormone</subject><subject>CRH</subject><subject>CRY</subject><subject>cryptochrome</subject><subject>CSF</subject><subject>DMH</subject><subject>dorsomedial nucleus of the hypothalamus</subject><subject>energy</subject><subject>energy metabolism</subject><subject>Energy Metabolism - physiology</subject><subject>FFA</subject><subject>forced desynchrony</subject><subject>free fatty acid</subject><subject>GABA</subject><subject>Gamma amino butyric acid</subject><subject>Glucose</subject><subject>GnRH</subject><subject>gonadotropin-releasing hormone</subject><subject>high energy foods</subject><subject>hormone sensitive lipase</subject><subject>Hormones - metabolism</subject><subject>HPA</subject><subject>HSL</subject><subject>Humans</subject><subject>hypothalamo-pituitary-adrenal</subject><subject>Hypothalamus</subject><subject>IML</subject><subject>intermediolateral column of the spinal cord</subject><subject>L/D</subject><subject>light/dark</subject><subject>lipoprotein lipase</subject><subject>Liver</subject><subject>LPL</subject><subject>medial preoptic area</subject><subject>Melatonin</subject><subject>messenger RNA</subject><subject>MPOA</subject><subject>mRNA</subject><subject>neuropeptide FF</subject><subject>neuropeptide Y</subject><subject>NPFF</subject><subject>NPY</subject><subject>Orexin</subject><subject>PACAP</subject><subject>paraventricular nucleus of the hypothalamus</subject><subject>pePVN</subject><subject>Per</subject><subject>period</subject><subject>periventricular nucleus of the hypothalamus</subject><subject>physical activity</subject><subject>pituitary adenylcyclase activating peptide</subject><subject>PVN</subject><subject>rate of (glucose) appearance</subject><subject>restricted feeding</subject><subject>SCN</subject><subject>SHR</subject><subject>society</subject><subject>SON</subject><subject>spontaneously hypertensive rat</subject><subject>subparaventricular nucleus of the hypothalamus</subject><subject>subPVN</subject><subject>suprachiasmatic nuclei</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Suprachiasmatic Nucleus - physiology</subject><subject>supraoptic nuclei</subject><subject>thyrotropin-releasing hormone</subject><subject>TRH</subject><subject>tyrosine hydroxylase</subject><subject>vasoactive intestinal peptide</subject><subject>ventromedial nucleus of the hypothalamus</subject><subject>VIP</subject><subject>VMH</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAURiMEotPCI4Cyg03Cvf6J7Q2ojFqKVMGisLYc2ykeZeLBzhTN2-PRTCvYUFa25eOjz_puVb1CaBGwe7dqB9_n0c8tAcQWaAsEn1QLlII2lHXyabUAQNZwoehJdZrzCspZonpenRBkyCiKRaWWIVnjgplqF3LabuYQp9pMrr5ZfqltnOYUxzoOtZ98ut3Vaz-bPo4hr19UzwYzZv_yuJ5V3y8vvi2vmuuvnz4vz68b23VENg6VAIOWcwemFwoFl0CNctYxaT2DflBMKdIRUIR0QDn3A2WKWxBgDaNn1fuDd7Pt195ZXyKZUW9SWJu009EE_ffNFH7o23inKSguOlUEb46CFH9ufZ71OmTrx9FMPm6zViiBEcL4o6TsBCWkhCvk23-SKCjlVILCgvIDalPMOfnhITqC3lepV_pYpd5XqYHqUmV59_rPfz-8uu-uAFcH4FcY_e7_rPry4iO52c_FfiwQy04wWVQfDipfirwLPulsg5-sdyF5O2sXwyNpfwNbRMYR</recordid><startdate>20110520</startdate><enddate>20110520</enddate><creator>Kalsbeek, Andries</creator><creator>Scheer, Frank A.</creator><creator>Perreau-Lenz, Stephanie</creator><creator>La Fleur, Susanne E.</creator><creator>Yi, Chun-Xia</creator><creator>Fliers, Eric</creator><creator>Buijs, Ruud M.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>7ST</scope><scope>7TK</scope><scope>C1K</scope><scope>SOI</scope><scope>5PM</scope></search><sort><creationdate>20110520</creationdate><title>Circadian disruption and SCN control of energy metabolism</title><author>Kalsbeek, Andries ; Scheer, Frank A. ; Perreau-Lenz, Stephanie ; La Fleur, Susanne E. ; Yi, Chun-Xia ; Fliers, Eric ; Buijs, Ruud M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6628-d1970a1c55d0ab79175803a9dcd48ce40bf9499262092260355ef3495c070ca43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ACTH</topic><topic>ad libitum</topic><topic>Adipose Tissue - metabolism</topic><topic>adrenocorticotrophic hormone</topic><topic>Animals</topic><topic>ANS</topic><topic>Autonomic nervous system</topic><topic>Autonomic Nervous System - metabolism</topic><topic>Autonomic Nervous System - physiology</topic><topic>biological clocks</topic><topic>Bmal</topic><topic>brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT) like</topic><topic>cardiovascular system</topic><topic>cerebrospinal fluid</topic><topic>circadian locomotor output cycles kaput</topic><topic>Circadian Rhythm - physiology</topic><topic>CLOCK</topic><topic>corticotrophin-releasing hormone</topic><topic>CRH</topic><topic>CRY</topic><topic>cryptochrome</topic><topic>CSF</topic><topic>DMH</topic><topic>dorsomedial nucleus of the hypothalamus</topic><topic>energy</topic><topic>energy metabolism</topic><topic>Energy Metabolism - physiology</topic><topic>FFA</topic><topic>forced desynchrony</topic><topic>free fatty acid</topic><topic>GABA</topic><topic>Gamma amino butyric acid</topic><topic>Glucose</topic><topic>GnRH</topic><topic>gonadotropin-releasing hormone</topic><topic>high energy foods</topic><topic>hormone sensitive lipase</topic><topic>Hormones - metabolism</topic><topic>HPA</topic><topic>HSL</topic><topic>Humans</topic><topic>hypothalamo-pituitary-adrenal</topic><topic>Hypothalamus</topic><topic>IML</topic><topic>intermediolateral column of the spinal cord</topic><topic>L/D</topic><topic>light/dark</topic><topic>lipoprotein lipase</topic><topic>Liver</topic><topic>LPL</topic><topic>medial preoptic area</topic><topic>Melatonin</topic><topic>messenger RNA</topic><topic>MPOA</topic><topic>mRNA</topic><topic>neuropeptide FF</topic><topic>neuropeptide Y</topic><topic>NPFF</topic><topic>NPY</topic><topic>Orexin</topic><topic>PACAP</topic><topic>paraventricular nucleus of the hypothalamus</topic><topic>pePVN</topic><topic>Per</topic><topic>period</topic><topic>periventricular nucleus of the hypothalamus</topic><topic>physical activity</topic><topic>pituitary adenylcyclase activating peptide</topic><topic>PVN</topic><topic>rate of (glucose) appearance</topic><topic>restricted feeding</topic><topic>SCN</topic><topic>SHR</topic><topic>society</topic><topic>SON</topic><topic>spontaneously hypertensive rat</topic><topic>subparaventricular nucleus of the hypothalamus</topic><topic>subPVN</topic><topic>suprachiasmatic nuclei</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Suprachiasmatic Nucleus - physiology</topic><topic>supraoptic nuclei</topic><topic>thyrotropin-releasing hormone</topic><topic>TRH</topic><topic>tyrosine hydroxylase</topic><topic>vasoactive intestinal peptide</topic><topic>ventromedial nucleus of the hypothalamus</topic><topic>VIP</topic><topic>VMH</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalsbeek, Andries</creatorcontrib><creatorcontrib>Scheer, Frank A.</creatorcontrib><creatorcontrib>Perreau-Lenz, Stephanie</creatorcontrib><creatorcontrib>La Fleur, Susanne E.</creatorcontrib><creatorcontrib>Yi, Chun-Xia</creatorcontrib><creatorcontrib>Fliers, Eric</creatorcontrib><creatorcontrib>Buijs, Ruud M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalsbeek, Andries</au><au>Scheer, Frank A.</au><au>Perreau-Lenz, Stephanie</au><au>La Fleur, Susanne E.</au><au>Yi, Chun-Xia</au><au>Fliers, Eric</au><au>Buijs, Ruud M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian disruption and SCN control of energy metabolism</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2011-05-20</date><risdate>2011</risdate><volume>585</volume><issue>10</issue><spage>1412</spage><epage>1426</epage><pages>1412-1426</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>21414317</pmid><doi>10.1016/j.febslet.2011.03.021</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | ACTH ad libitum Adipose Tissue - metabolism adrenocorticotrophic hormone Animals ANS Autonomic nervous system Autonomic Nervous System - metabolism Autonomic Nervous System - physiology biological clocks Bmal brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT) like cardiovascular system cerebrospinal fluid circadian locomotor output cycles kaput Circadian Rhythm - physiology CLOCK corticotrophin-releasing hormone CRH CRY cryptochrome CSF DMH dorsomedial nucleus of the hypothalamus energy energy metabolism Energy Metabolism - physiology FFA forced desynchrony free fatty acid GABA Gamma amino butyric acid Glucose GnRH gonadotropin-releasing hormone high energy foods hormone sensitive lipase Hormones - metabolism HPA HSL Humans hypothalamo-pituitary-adrenal Hypothalamus IML intermediolateral column of the spinal cord L/D light/dark lipoprotein lipase Liver LPL medial preoptic area Melatonin messenger RNA MPOA mRNA neuropeptide FF neuropeptide Y NPFF NPY Orexin PACAP paraventricular nucleus of the hypothalamus pePVN Per period periventricular nucleus of the hypothalamus physical activity pituitary adenylcyclase activating peptide PVN rate of (glucose) appearance restricted feeding SCN SHR society SON spontaneously hypertensive rat subparaventricular nucleus of the hypothalamus subPVN suprachiasmatic nuclei Suprachiasmatic Nucleus - metabolism Suprachiasmatic Nucleus - physiology supraoptic nuclei thyrotropin-releasing hormone TRH tyrosine hydroxylase vasoactive intestinal peptide ventromedial nucleus of the hypothalamus VIP VMH |
| title | Circadian disruption and SCN control of energy metabolism |
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