Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation

Pax3, a member of the paired class homeodomain family of transcription factors, is essential for early skeletal muscle development and is key in the development of the childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by a t(2;13)(q35;q14) chromosomal tra...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2011-06, Vol.43 (6), p.936-945
Hauptverfasser:	Dietz, Kevin N., Miller, Patrick J., Iyengar, Aditi S., Loupe, Jacob M., Hollenbach, Andrew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar rhabdomyosarcoma Animals antibodies Antibodies, Phospho-Specific - metabolism Biomedical materials Casein Kinase II - metabolism cell differentiation Cell Line, Tumor Child childhood chromosome translocation Differentiation Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans In vivo testing Kinases Mathematical models Mice Mice, Inbred C57BL Muscle Development Muscle Neoplasms - metabolism Muscle Neoplasms - pathology Muscles myoblasts Myoblasts - metabolism Myoblasts - pathology Myogenesis Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - immunology Oncogene Proteins, Fusion - metabolism Paired Box Transcription Factors - genetics Paired Box Transcription Factors - immunology Paired Box Transcription Factors - metabolism Pax3 PAX3 Transcription Factor Pax3-FOXO1 Phosphorylation Proteins Rhabdomyosarcoma, Alveolar - metabolism Rhabdomyosarcoma, Alveolar - pathology serine Serine - genetics skeletal muscle tau-protein kinase transcription factors
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