Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons

Dlx transcription factors are important in the differentiation of GABAergic interneurons. In mice lacking Dlx1, early steps in interneuron development appear normal. Beginning at ∼ 1 mo of age, primarily dendrite-innervating interneuron subtypes begin to undergo apoptosis in Dlx1(-/-) mice; this is...

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Veröffentlicht in:	Journal of neurophysiology 2011-05, Vol.105 (5), p.1984-1991
Hauptverfasser:	Jones, Daniel L, Howard, MacKenzie A, Stanco, Amelia, Rubenstein, John L R, Baraban, Scott C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals CA1 Region, Hippocampal - physiology Excitatory Postsynaptic Potentials - physiology gamma-Aminobutyric Acid - physiology Gene Deletion Glutamic Acid - physiology Hippocampus - physiology Homeodomain Proteins - genetics Interneurons - physiology Mice Mice, Knockout Neural Pathways - physiology Transcription Factors - deficiency Transcription Factors - genetics
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