Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase

Tob is a member of the anti‐proliferative protein family, which functions in transcription and mRNA decay. We have previously demonstrated that Tob is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with Caf1 and a general RNA‐binding protein, PABP...

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Veröffentlicht in:	The EMBO journal 2011-04, Vol.30 (7), p.1311-1323
Hauptverfasser:	Hosoda, Nao, Funakoshi, Yuji, Hirasawa, Masato, Yamagishi, Ryota, Asano, Yukako, Miyagawa, Ryu, Ogami, Koichi, Tsujimoto, Masafumi, Hoshino, Shin-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Caf1 Cercopithecus aethiops Chemical elements COS Cells CPEB3 deadenylation Decay EMBO36 Gene Expression Regulation HeLa Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Proteins Ribonucleic acid RNA RNA Stability RNA, Messenger - metabolism RNA-Binding Proteins - antagonists & inhibitors Tob Transcription Factors - antagonists & inhibitors Tumor Suppressor Proteins - metabolism
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