S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning. S1P lyase (SPL) is a stress-activated enzyme responsible for irreversible S1P catabolism. We hypothesized that SPL contributes to oxidative stress by depleting...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2011-05, Vol.300 (5), p.H1753-H1761
Hauptverfasser:	Bandhuvula, Padmavathi, Honbo, Norman, Wang, Guan-Ying, Jin, Zhu-Qiu, Fyrst, Henrik, Zhang, Meng, Borowsky, Alexander D, Dillard, Lisa, Karliner, Joel S, Saba, Julie D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde-Lyases - antagonists & inhibitors Aldehyde-Lyases - genetics Aldehyde-Lyases - physiology Animals Correlation analysis Enzyme Inhibitors - therapeutic use Food additives Heart Ischemia Kinases Lysophospholipids - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Mutation - genetics Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Oxidative Stress - physiology Phosphorylation Rodents Signaling and Stress Response Sphingosine - analogs & derivatives Sphingosine - metabolism
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