Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing NO production. Elevated angiotensin II (ANG II) is a key component of endothelial dysfunction in many cardiovascular dise...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2011-05, Vol.300 (5), p.C1181-C1192
Hauptverfasser:	Shatanawi, Alia, Romero, Maritza J, Iddings, Jennifer A, Chandra, Surabhi, Umapathy, Nagavedi S, Verin, Alexander D, Caldwell, Ruth B, Caldwell, R William
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology ACE inhibitors Amides - pharmacology Angiotensin II - pharmacology Angiotensin II - physiology Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Arginase - antagonists & inhibitors Arginase - physiology Boronic Acids - pharmacology Cardiovascular disease Cattle Cell Line Cells Endothelial Cells Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - physiopathology Enzyme Inhibitors - pharmacology GTP-Binding Protein alpha Subunits, G12-G13 - antagonists & inhibitors GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors Imidazoles - pharmacology Mice Nitric oxide p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - physiology Phosphorylation Proteins Pyridines - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - physiology RNA, Small Interfering - pharmacology Rodents Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Simvastatin - pharmacology Vascular Biology
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