Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein

The molecule (S)-4,5-dihydroxy-2,3-pentanedione (DPD) is produced by many different species of bacteria and is the precursor of the signal molecule autoinducer-2 (AI-2). AI-2 mediates interspecies communication and facilitates regulation of bacterial behaviors such as biofilm formation and virulence...

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Veröffentlicht in:	The Journal of biological chemistry 2011-05, Vol.286 (20), p.18331-18343
Hauptverfasser:	Marques, João C, Lamosa, Pedro, Russell, Caitlin, Ventura, Rita, Maycock, Christopher, Semmelhack, Martin F, Miller, Stephen T, Xavier, Karina B
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Enzymology Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Deletion Homoserine - analogs & derivatives Homoserine - chemistry Homoserine - metabolism Lactones - chemistry Lactones - metabolism Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Operon - physiology Pentanones - chemistry Pentanones - metabolism Protein Structure, Tertiary Quorum Sensing - physiology
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