4′-Thio-oligo-β-D-ribonucleotides: synthesis of β-4′-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase

We present the synthesis and the study of properties of a new series of modified oligonucleotides, namely 4′-thio-oligo-β-D-ribonucleotides (4′-S-RNA). Homo-oligonucleotides of this class (4′-SU6 and 4′-SU12) were prepared from the previously known thionucleosides using the phosphoramidite methodolo...

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