Array comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma

Abstract Background Cholangiocarcinoma (CC) is a rare tumour with a dismal prognosis. As conventional medical management offers minimal survival benefit, surgery currently represents the only chance of cure. We evaluated DNA copy number (CN) alterations in CC to identify novel therapeutic targets. M...

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Veröffentlicht in:	HPB (Oxford, England) England), 2011-05, Vol.13 (5), p.309-319
Hauptverfasser:	McKay, Siobhan C, Unger, Kristian, Pericleous, Stephanos, Stamp, Gordon, Thomas, Gerry, Hutchins, Robert R, Spalding, Duncan R.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Bile Duct Neoplasms - chemistry Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - genetics Bile Duct Neoplasms - pathology Bile Duct Neoplasms - therapy Bile Ducts, Intrahepatic - chemistry Bile Ducts, Intrahepatic - pathology Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics cholangiocarcinoma Cholangiocarcinoma - chemistry Cholangiocarcinoma - diagnosis Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Cholangiocarcinoma - therapy Chromosomes, Artificial, Bacterial Comparative Genomic Hybridization DNA copy number change DNA Copy Number Variations Female Gastroenterology and Hepatology Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Genetic Testing Humans Immunohistochemistry Male Middle Aged Molecular Targeted Therapy Oligonucleotide Array Sequence Analysis Original Patient Selection Precision Medicine Predictive Value of Tests Prognosis Receptor, ErbB-2 - analysis Receptor, ErbB-2 - genetics
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