Perpetrators of pharmacokinetic drug–drug interactions arising from altered cytochrome P450 activity: a criteria‐based assessment

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Many drugs inhibit or induce cytochrome P450 enzymes (CYP) to cause clinically significant changes in the concentrations of other drugs, i.e. ‘perpetrate’ pharmacokinetic drug–drug interactions (PK‐DDIs). • Tables that list the substrates, inhibitors and in...

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Veröffentlicht in:	British journal of clinical pharmacology 2011-05, Vol.71 (5), p.727-736
Hauptverfasser:	Polasek, Thomas M., Lin, Frank P. Y., Miners, John O., Doogue, Matthew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catalogs, Drug CYP CYP induction CYP inhibition Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - physiology cytochromes P450 Drug Interactions Drug Interactions - physiology drug–drug interactions Enzyme Induction Enzyme Inhibitors - pharmacology Evidence-Based Medicine - methods Humans Medical sciences pharmacokinetics Pharmacology. Drug treatments
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