Differential regulation of spontaneous and evoked neurotransmitter release at central synapses

Differential regulation of spontaneous and evoked neurotransmitter release at central synapses

Research highlights ► Postsynaptic target and presynaptic origin of evoked and spontaneous release diverge. ► Several regulatory pathways impact spontaneous and evoked release differently. ► Classical assumptions linking evoked and spontaneous neurotransmission need revision. ► Mechanisms that under...

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Veröffentlicht in:Current opinion in neurobiology 2011-04, Vol.21 (2), p.275-282
Hauptverfasser: Ramirez, Denise MO, Kavalali, Ege T
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - metabolism
Humans
Neurology
Neurotransmitter Agents - metabolism
Psychiatry
Synapses - metabolism
Synaptic Transmission - physiology
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Zusammenfassung:Research highlights ► Postsynaptic target and presynaptic origin of evoked and spontaneous release diverge. ► Several regulatory pathways impact spontaneous and evoked release differently. ► Classical assumptions linking evoked and spontaneous neurotransmission need revision. ► Mechanisms that underlie the divergent regulation of neurotransmission are discussed.
ISSN:0959-4388
1873-6882
1873-6882
DOI:10.1016/j.conb.2011.01.007