FKBP12 Is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-Gated Sodium Current in Mice

RATIONALE:FK506 binding protein (FKBP)12 is a known cis-trans peptidyl prolyl isomerase and highly expressed in the heart. Its role in regulating postnatal cardiac function remains largely unknown. METHODS AND RESULTS:We generated FKBP12 overexpressing transgenic (αMyHC-FKBP12) mice and cardiomyocyt...

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Veröffentlicht in:	Circulation research 2011-04, Vol.108 (9), p.1042-1052
Hauptverfasser:	Maruyama, Mitsunori, Li, Bai-Yan, Chen, Hanying, Xu, Xuehong, Song, Long-Sheng, Guatimosim, Silvia, Zhu, Wuqiang, Yong, Weidong, Zhang, Wenjun, Bu, Guixue, Lin, Shien-Fong, Fishbein, Michael C, Lederer, W Jonathan, Schild, John H, Field, Loren J, Rubart, Michael, Chen, Peng-Sheng, Shou, Weinian
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - physiopathology Biological and medical sciences Calcium - metabolism Calcium Channels, L-Type - physiology Cardiac dysrhythmias Cardiology. Vascular system Fundamental and applied biological sciences. Psychology Heart Heart Conduction System - physiology In Vitro Techniques Integrases - genetics Long QT Syndrome - genetics Long QT Syndrome - physiopathology Medical sciences Mice Mice, Knockout Myocardial Contraction - physiology Myocytes, Cardiac - physiology Patch-Clamp Techniques Potassium Channels - physiology Sodium Channels - physiology Tacrolimus Binding Protein 1A - genetics Tacrolimus Binding Protein 1A - metabolism Vertebrates: cardiovascular system
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