A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor

Angiogenesis plays an essential role in several diseases of the eye and in the growth of solid tumors, but existing antiangiogenic therapies have limited benefits in several cases. We report the antiangiogenic effects of a monoclonal antibody, CL1-R2, in several animal models of neovascularization....

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Veröffentlicht in:	The Journal of experimental medicine 2011-05, Vol.208 (5), p.973-986
Hauptverfasser:	Chabot, Sophie, Jabrane-Ferrat, Nabila, Bigot, Karine, Tabiasco, Julie, Provost, Alexandra, Golzio, Muriel, Noman, Muhammad Zaeem, Giustiniani, Jérôme, Bellard, Elisabeth, Brayer, Stéphanie, Aguerre-Girr, Maryse, Meggetto, Fabienne, Giuriato, Sylvie, Malecaze, François, Galiacy, Stéphane, Jaïs, Jean-Philippe, Chose, Olivier, Kadouche, Jean, Chouaib, Salem, Teissié, Justin, Abitbol, Marc, Bensussan, Armand, Le Bouteiller, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Murine-Derived Antibodies, Monoclonal, Murine-Derived - pharmacology Antigens, CD Antigens, CD - genetics Antigens, CD - metabolism Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols - pharmacology Cancer Colonic Neoplasms Colonic Neoplasms - blood supply Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Corneal Neovascularization Corneal Neovascularization - drug therapy Corneal Neovascularization - genetics Corneal Neovascularization - metabolism Corneal Neovascularization - pathology Cyclophosphamide Cyclophosphamide - pharmacology Female Fibroblast Growth Factor 2 Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism GPI-Linked Proteins GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Humans Life Sciences Male Melanoma Melanoma - blood supply Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred BALB C Mice, Nude Neovascularization, Pathologic Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Rabbits Receptors, Immunologic Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Retinal Diseases Retinal Diseases - drug therapy Retinal Diseases - genetics Retinal Diseases - metabolism Retinal Diseases - pathology
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