Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments

Summary Homeostasis of intracellular pH is a trait critical for survival of Mycobacterium tuberculosis in macrophages. However, mechanisms by which M. tuberculosis adapts to acidic environments are poorly understood. In this study, we analysed the physiological functions of OmpATb, a surface‐accessi...

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Veröffentlicht in:	Molecular microbiology 2011-05, Vol.80 (4), p.900-918
Hauptverfasser:	Song, Houhui, Huff, Jason, Janik, Katharine, Walter, Kerstin, Keller, Christine, Ehlers, Stefan, Bossmann, Stefan H., Niederweis, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Adaptation, Physiological Ammonia Ammonia - metabolism Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Bacterial Glucose Gram-positive bacteria Homeostasis Hydrogen-Ion Concentration Mice Mice, Inbred BALB C Microbiology Miscellaneous Mutation Mycobacterium smegmatis Mycobacterium smegmatis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - metabolism Operon Porins - genetics Porins - metabolism Rodents Sequence Deletion Studies Tuberculosis Tuberculosis - microbiology
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