Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia

Progranulin (GRN) haploinsufficiency is a frequent cause of familial frontotemporal dementia, a currently untreatable progressive neurodegenerative disease. By chemical library screening, we identified suberoylanilide hydroxamic acid (SAHA), a Food and Drug Administration-approved histone deacetylas...

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Veröffentlicht in:	The Journal of biological chemistry 2011-05, Vol.286 (18), p.16101-16108
Hauptverfasser:	Cenik, Basar, Sephton, Chantelle F, Dewey, Colleen M, Xian, Xunde, Wei, Shuguang, Yu, Kimberley, Niu, Wenze, Coppola, Giovanni, Coughlin, Sarah E, Lee, Suzee E, Dries, Daniel R, Almeida, Sandra, Geschwind, Daniel H, Gao, Fen-Biao, Miller, Bruce L, Farese, Jr, Robert V, Posner, Bruce A, Yu, Gang, Herz, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Frontotemporal Dementia - drug therapy Frontotemporal Dementia - metabolism HEK293 Cells Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Intercellular Signaling Peptides and Proteins - biosynthesis Neurobiology Progranulins Transcription, Genetic - drug effects Up-Regulation - drug effects Vorinostat
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