Intertissue flow of glutathione (GSH) as a tumor growth-promoting mechanism: interleukin 6 induces GSH release from hepatocytes in metastatic B16 melanoma-bearing mice

B16 melanoma F10 (B16-F10) cells with high glutathione (GSH) content show high metastatic activity in vivo. An intertissue flow of GSH, where the liver is the main reservoir, can increase GSH content in metastatic cells and promote their growth. We have studied here possible tumor-derived molecular...

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Veröffentlicht in:	The Journal of biological chemistry 2011-05, Vol.286 (18), p.15716-15727
Hauptverfasser:	Obrador, Elena, Benlloch, María, Pellicer, José A, Asensi, Miguel, Estrela, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Cell Line, Tumor Glutathione - genetics Glutathione - metabolism Hepatocytes - metabolism Hepatocytes - pathology Interleukin-6 - genetics Interleukin-6 - metabolism Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Molecular Bases of Disease Neoplasm Metastasis STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism
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