Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer

Gemcitabine, while a standard treatment of advanced pancreatic cancer (PaCa), alone is not very effective. New agents that are safe and effective are highly needed. Resveratrol is one such agent which is safe and multitargeted; and has been linked with suppression of survival, proliferation, invasio...

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Veröffentlicht in:	International journal of cancer 2010-07, Vol.127 (2), p.257-268
Hauptverfasser:	Harikumar, Kuzhuvelil B., Kunnumakkara, Ajaikumar B., Sethi, Gautam, Diagaradjane, Parmeswaran, Anand, Preetha, Pandey, Manoj K., Gelovani, Juri, Krishnan, Sunil, Guha, Sushovan, Aggarwal, Bharat B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Cycle - drug effects Cell Proliferation - drug effects chemoresistance chemotherapeutic agents Cyclooxygenase 2 - metabolism Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Gastroenterology. Liver. Pancreas. Abdomen Gemcitabine Humans Immunoenzyme Techniques In Vitro Techniques Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, Nude NF-kappa B - genetics NF-kappa B - metabolism NF‐κB pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Resveratrol Stilbenes - administration & dosage Tumor Cells, Cultured Tumors Vascular Endothelial Growth Factor A - metabolism Xenograft Model Antitumor Assays
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