The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells

► A novel VDRE is identified in the intron 1 of EGFR genome, a hotspot for the transcriptional control of EGFR mRNA expression. ► The VDRE binds in vivo to the VDR and a corepressor. ► The EGFR down regulation contributes to the suppression of ovarian cancer cell growth to 1,25(OH) 2D 3. ► The EGFR...

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Veröffentlicht in:	Molecular and cellular endocrinology 2011-05, Vol.338 (1), p.58-67
Hauptverfasser:	Shen, Zheng, Zhang, Xiaohui, Tang, Jinfu, Kasiappan, Ravi, Jinwal, Umesh, Li, Pengfei, Hann, Shan, Nicosia, Santo V., Wu, Jie, Zhang, Xiaohong, Bai, Wenlong
Format:	Artikel
Sprache:	eng
Schlagworte:	animal ovaries Calcitriol - pharmacology Cancer Cell cycle Cell Line, Tumor Cell Proliferation - drug effects chromatin Control Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclins - metabolism DNA Down-Regulation - drug effects EGF EGFR epidermal growth factor Epidermal Growth Factor - pharmacology epidermal growth factor receptors Female G1 Phase - drug effects gene expression Gene Expression Regulation, Neoplastic - drug effects Genes Genes, Reporter Growth factors hormonal regulation Human Humans Introns Kinases Luciferases, Firefly - biosynthesis Luciferases, Firefly - genetics messenger RNA neoplasm cells Ovarian cancer ovarian neoplasms Ovarian Neoplasms - physiopathology precipitin tests Receptor, Epidermal Growth Factor - agonists Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Receptors reporter genes Signal Transduction transcription (genetics) transfection Vitamin D Vitamin D receptor Vitamin D Response Element Vitamins
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