Molecular determinants of origin discrimination by Orc1 initiators in archaea

Unlike bacteria, many eukaryotes initiate DNA replication from genomic sites that lack apparent sequence conservation. These loci are identified and bound by the origin recognition complex (ORC), and subsequently activated by a cascade of events that includes recruitment of an additional factor, Cdc...

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Veröffentlicht in:	Nucleic acids research 2011-05, Vol.39 (9), p.3621-3631
Hauptverfasser:	Dueber, Erin C, Costa, Alessandro, Corn, Jacob E, Bell, Stephen D, Berger, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaea Archaeal Proteins - chemistry Archaeal Proteins - metabolism DNA, Archaeal - chemistry DNA, Archaeal - metabolism Genome Integrity, Repair and Origin Recognition Complex - chemistry Origin Recognition Complex - metabolism Protein Binding Protein Structure, Tertiary Replication Origin Sulfolobus solfataricus Sulfolobus solfataricus - genetics
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