SGK3 Is an Estrogen-Inducible Kinase Promoting Estrogen-Mediated Survival of Breast Cancer Cells

Serum- and glucocorticoid-inducible kinase 3 (SGK3) is a protein kinase of the AGC family of protein kinase A, protein kinase G, and protein kinase C and functions downstream of phosphatidylinositol 3-kinase (PI3K). Recent study revealed that SGK3 plays a pivotal role in Akt/protein kinase B indepen...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2011-01, Vol.25 (1), p.72-82
Hauptverfasser:	Wang, Yuanzhong, Zhou, Dujin, Phung, Sheryl, Masri, Selma, Smith, David, Chen, Shiuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Base Sequence Binding Sites Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Line, Tumor Cell Survival - drug effects Cytoprotection - drug effects Enzyme Induction - drug effects Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogens - pharmacology Female Genetic Loci - genetics Humans Models, Biological Molecular Sequence Data Promoter Regions, Genetic - genetics Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction - drug effects Transcription, Genetic - drug effects Transcriptional Activation - drug effects
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