Hospitalization Rates Before and After Adult-to-Adult Living Donor or Deceased Donor Liver Transplantation
To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT). LDLT recipients have been reported to have lower mortality but a higher complication rate than DDLT recipients. The higher complication rate may be ass...
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| Veröffentlicht in: | Annals of surgery 2010-03, Vol.251 (3), p.542-549 |
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| creator | MERION, Robert M SHEARON, Tempie H HAYASHI, Paul H HONG, Johnny C BERG, Carl L EVERHART, James E ABECASSIS, Michael M SHAKED, Abraham FISHER, Robert A TROTTER, James F BROWN, Robert S TERRAULT, Norah A |
| description | To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT).
LDLT recipients have been reported to have lower mortality but a higher complication rate than DDLT recipients. The higher complication rate may be associated with greater consumption of inpatient hospital resources and a higher burden of disease for LDLT recipients.
Data from the 9-center Adult-to-Adult Living Donor Liver Transplantation retrospective cohort study were analyzed to determine pretransplant, transplant, and posttransplant hospitalizations among LDLT candidates (potential living donor was evaluated) who received LDLT or DDLT. Hospital days and admission rates for LDLT and DDLT patients were calculated per patient-year at risk, starting from the date of initial potential donor history and physical examination. Rates were compared using overdispersed Poisson regression models.
Among 806 candidates, 384 received LDLT and 215 received DDLT. In addition to the 599 transplants, there were 1913 recipient hospitalizations (485 pretransplant; 1428 posttransplant). Mean DDLT recipient pretransplant, transplant, and posttransplant lengths of stay were 5.8 +/- 6.3, 27.0 +/- 32.6, and 9.0 +/- 14.1 days, respectively, and for LDLT were 4.1 +/- 3.7, 21.4 +/- 24.3, and 7.8 +/- 11.4 days, respectively. Compared with DDLT, LDLT recipients had significantly lower adjusted pretransplant hospital day and admission rates, but significantly higher posttransplant rates. Significantly higher LDLT admission rates were observed for biliary tract morbidity throughout the second posttransplant year. Overall hospitalization rates starting from the point of potential donor evaluation were significantly higher for eventual recipients of LDLT.
LDLT recipients, despite lower acuity of disease, have higher hospitalization requirements when compared with DDLT recipients. Continuing efforts are warranted to reduce the incidence of complications requiring post-LDLT inpatient admission, with particular emphasis on biliary tract issues. |
| doi_str_mv | 10.1097/sla.0b013e3181ccb370 |
| format | Article |
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LDLT recipients have been reported to have lower mortality but a higher complication rate than DDLT recipients. The higher complication rate may be associated with greater consumption of inpatient hospital resources and a higher burden of disease for LDLT recipients.
Data from the 9-center Adult-to-Adult Living Donor Liver Transplantation retrospective cohort study were analyzed to determine pretransplant, transplant, and posttransplant hospitalizations among LDLT candidates (potential living donor was evaluated) who received LDLT or DDLT. Hospital days and admission rates for LDLT and DDLT patients were calculated per patient-year at risk, starting from the date of initial potential donor history and physical examination. Rates were compared using overdispersed Poisson regression models.
Among 806 candidates, 384 received LDLT and 215 received DDLT. In addition to the 599 transplants, there were 1913 recipient hospitalizations (485 pretransplant; 1428 posttransplant). Mean DDLT recipient pretransplant, transplant, and posttransplant lengths of stay were 5.8 +/- 6.3, 27.0 +/- 32.6, and 9.0 +/- 14.1 days, respectively, and for LDLT were 4.1 +/- 3.7, 21.4 +/- 24.3, and 7.8 +/- 11.4 days, respectively. Compared with DDLT, LDLT recipients had significantly lower adjusted pretransplant hospital day and admission rates, but significantly higher posttransplant rates. Significantly higher LDLT admission rates were observed for biliary tract morbidity throughout the second posttransplant year. Overall hospitalization rates starting from the point of potential donor evaluation were significantly higher for eventual recipients of LDLT.
LDLT recipients, despite lower acuity of disease, have higher hospitalization requirements when compared with DDLT recipients. Continuing efforts are warranted to reduce the incidence of complications requiring post-LDLT inpatient admission, with particular emphasis on biliary tract issues.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/sla.0b013e3181ccb370</identifier><identifier>PMID: 20130466</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Age Factors ; Biological and medical sciences ; Female ; General aspects ; Hospitalization - statistics & numerical data ; Humans ; Liver Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Living Donors ; Male ; Medical sciences ; Middle Aged ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Tissue Donors</subject><ispartof>Annals of surgery, 2010-03, Vol.251 (3), p.542-549</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-8e86f5f95e7103b91fc192f5b6410c62cc0aa0fd904b69a90bcb26e46d5974b43</citedby><cites>FETCH-LOGICAL-c503t-8e86f5f95e7103b91fc192f5b6410c62cc0aa0fd904b69a90bcb26e46d5974b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088992/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088992/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22555797$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20130466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MERION, Robert M</creatorcontrib><creatorcontrib>SHEARON, Tempie H</creatorcontrib><creatorcontrib>HAYASHI, Paul H</creatorcontrib><creatorcontrib>HONG, Johnny C</creatorcontrib><creatorcontrib>BERG, Carl L</creatorcontrib><creatorcontrib>EVERHART, James E</creatorcontrib><creatorcontrib>ABECASSIS, Michael M</creatorcontrib><creatorcontrib>SHAKED, Abraham</creatorcontrib><creatorcontrib>FISHER, Robert A</creatorcontrib><creatorcontrib>TROTTER, James F</creatorcontrib><creatorcontrib>BROWN, Robert S</creatorcontrib><creatorcontrib>TERRAULT, Norah A</creatorcontrib><creatorcontrib>A2ALL Study Group</creatorcontrib><title>Hospitalization Rates Before and After Adult-to-Adult Living Donor or Deceased Donor Liver Transplantation</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT).
LDLT recipients have been reported to have lower mortality but a higher complication rate than DDLT recipients. The higher complication rate may be associated with greater consumption of inpatient hospital resources and a higher burden of disease for LDLT recipients.
Data from the 9-center Adult-to-Adult Living Donor Liver Transplantation retrospective cohort study were analyzed to determine pretransplant, transplant, and posttransplant hospitalizations among LDLT candidates (potential living donor was evaluated) who received LDLT or DDLT. Hospital days and admission rates for LDLT and DDLT patients were calculated per patient-year at risk, starting from the date of initial potential donor history and physical examination. Rates were compared using overdispersed Poisson regression models.
Among 806 candidates, 384 received LDLT and 215 received DDLT. In addition to the 599 transplants, there were 1913 recipient hospitalizations (485 pretransplant; 1428 posttransplant). Mean DDLT recipient pretransplant, transplant, and posttransplant lengths of stay were 5.8 +/- 6.3, 27.0 +/- 32.6, and 9.0 +/- 14.1 days, respectively, and for LDLT were 4.1 +/- 3.7, 21.4 +/- 24.3, and 7.8 +/- 11.4 days, respectively. Compared with DDLT, LDLT recipients had significantly lower adjusted pretransplant hospital day and admission rates, but significantly higher posttransplant rates. Significantly higher LDLT admission rates were observed for biliary tract morbidity throughout the second posttransplant year. Overall hospitalization rates starting from the point of potential donor evaluation were significantly higher for eventual recipients of LDLT.
LDLT recipients, despite lower acuity of disease, have higher hospitalization requirements when compared with DDLT recipients. Continuing efforts are warranted to reduce the incidence of complications requiring post-LDLT inpatient admission, with particular emphasis on biliary tract issues.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Liver Transplantation</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Tissue Donors</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9rFDEUxYModq1-AynzIn2aejP5M5OXwrZVKywIbX0OSeampsxOtkm2UD-9sV2rFQIJub9zcm8OIe8pHFFQ_cc8mSOwQBkyOlDnLOvhBVlQ0Q0tpRxekgUAsJYr1u2RNznfAFA-QP-a7HVVBlzKBbk5j3kTipnCT1NCnJsLUzA3J-hjwsbMY7P0BVOzHLdTaUtsHw7NKtyF-bo5i3NMTV1n6NBkHHc3tVw1V8nMeTOZuTxYvyWvvJkyvtvt--T7509Xp-ft6tuXr6fLVesEsNIOOEgvvBLYU2BWUe-o6rywklNwsnMOjAE_KuBWKqPAOttJ5HIUqueWs31y_Oi72do1jg7nksykNymsTbrX0QT9vDKHH_o63mkGw6BUVw0OdwYp3m4xF70O2eFUJ8G4zbpnTArFQFSSP5IuxZwT-qdXKOjfKenL1VL_n1KVHfzb4ZPoTywV-LADTHZm8vUjXch_uU4I0aue_QLkAZ5O</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>MERION, Robert M</creator><creator>SHEARON, Tempie H</creator><creator>HAYASHI, Paul H</creator><creator>HONG, Johnny C</creator><creator>BERG, Carl L</creator><creator>EVERHART, James E</creator><creator>ABECASSIS, Michael M</creator><creator>SHAKED, Abraham</creator><creator>FISHER, Robert A</creator><creator>TROTTER, James F</creator><creator>BROWN, Robert S</creator><creator>TERRAULT, Norah A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Hospitalization Rates Before and After Adult-to-Adult Living Donor or Deceased Donor Liver Transplantation</title><author>MERION, Robert M ; SHEARON, Tempie H ; HAYASHI, Paul H ; HONG, Johnny C ; BERG, Carl L ; EVERHART, James E ; ABECASSIS, Michael M ; SHAKED, Abraham ; FISHER, Robert A ; TROTTER, James F ; BROWN, Robert S ; TERRAULT, Norah A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-8e86f5f95e7103b91fc192f5b6410c62cc0aa0fd904b69a90bcb26e46d5974b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Liver Transplantation</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MERION, Robert M</creatorcontrib><creatorcontrib>SHEARON, Tempie H</creatorcontrib><creatorcontrib>HAYASHI, Paul H</creatorcontrib><creatorcontrib>HONG, Johnny C</creatorcontrib><creatorcontrib>BERG, Carl L</creatorcontrib><creatorcontrib>EVERHART, James E</creatorcontrib><creatorcontrib>ABECASSIS, Michael M</creatorcontrib><creatorcontrib>SHAKED, Abraham</creatorcontrib><creatorcontrib>FISHER, Robert A</creatorcontrib><creatorcontrib>TROTTER, James F</creatorcontrib><creatorcontrib>BROWN, Robert S</creatorcontrib><creatorcontrib>TERRAULT, Norah A</creatorcontrib><creatorcontrib>A2ALL Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MERION, Robert M</au><au>SHEARON, Tempie H</au><au>HAYASHI, Paul H</au><au>HONG, Johnny C</au><au>BERG, Carl L</au><au>EVERHART, James E</au><au>ABECASSIS, Michael M</au><au>SHAKED, Abraham</au><au>FISHER, Robert A</au><au>TROTTER, James F</au><au>BROWN, Robert S</au><au>TERRAULT, Norah A</au><aucorp>A2ALL Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hospitalization Rates Before and After Adult-to-Adult Living Donor or Deceased Donor Liver Transplantation</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>251</volume><issue>3</issue><spage>542</spage><epage>549</epage><pages>542-549</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT).
LDLT recipients have been reported to have lower mortality but a higher complication rate than DDLT recipients. The higher complication rate may be associated with greater consumption of inpatient hospital resources and a higher burden of disease for LDLT recipients.
Data from the 9-center Adult-to-Adult Living Donor Liver Transplantation retrospective cohort study were analyzed to determine pretransplant, transplant, and posttransplant hospitalizations among LDLT candidates (potential living donor was evaluated) who received LDLT or DDLT. Hospital days and admission rates for LDLT and DDLT patients were calculated per patient-year at risk, starting from the date of initial potential donor history and physical examination. Rates were compared using overdispersed Poisson regression models.
Among 806 candidates, 384 received LDLT and 215 received DDLT. In addition to the 599 transplants, there were 1913 recipient hospitalizations (485 pretransplant; 1428 posttransplant). Mean DDLT recipient pretransplant, transplant, and posttransplant lengths of stay were 5.8 +/- 6.3, 27.0 +/- 32.6, and 9.0 +/- 14.1 days, respectively, and for LDLT were 4.1 +/- 3.7, 21.4 +/- 24.3, and 7.8 +/- 11.4 days, respectively. Compared with DDLT, LDLT recipients had significantly lower adjusted pretransplant hospital day and admission rates, but significantly higher posttransplant rates. Significantly higher LDLT admission rates were observed for biliary tract morbidity throughout the second posttransplant year. Overall hospitalization rates starting from the point of potential donor evaluation were significantly higher for eventual recipients of LDLT.
LDLT recipients, despite lower acuity of disease, have higher hospitalization requirements when compared with DDLT recipients. Continuing efforts are warranted to reduce the incidence of complications requiring post-LDLT inpatient admission, with particular emphasis on biliary tract issues.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20130466</pmid><doi>10.1097/sla.0b013e3181ccb370</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of surgery, 2010-03, Vol.251 (3), p.542-549 |
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| source | MEDLINE; Journals@Ovid Complete - AutoHoldings; PubMed Central |
| subjects | Age Factors Biological and medical sciences Female General aspects Hospitalization - statistics & numerical data Humans Liver Transplantation Liver, biliary tract, pancreas, portal circulation, spleen Living Donors Male Medical sciences Middle Aged Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue Donors |
| title | Hospitalization Rates Before and After Adult-to-Adult Living Donor or Deceased Donor Liver Transplantation |
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