Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection

Summary The programmed death ligands 1 (PD‐L1) and 2 (PD‐L2) that bind to programmed death 1 (PD‐1) have been involved in peripheral tolerance and in the immune escape mechanisms during chronic viral infections and cancer. However, there are no reports about the role of these molecules during Trypan...

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Veröffentlicht in:	Immunology 2011-05, Vol.133 (1), p.29-40
Hauptverfasser:	Dulgerian, Laura R., Garrido, Vanina V., Stempin, Cinthia C., Cerbán, Fabio M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arginase Arginase - biosynthesis Arginase - immunology B7-1 Antigen - immunology B7-1 Antigen - metabolism Blotting, Western Cell Separation Chagas Disease - immunology Chagas Disease - metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Flow Cytometry inducible nitric oxide synthase macrophage Macrophages - immunology Macrophages - metabolism Macrophages - parasitology Mice Mice, Inbred BALB C Mice, Knockout Nitric Oxide Synthase Type II - immunology Nitric Oxide Synthase Type II - metabolism Original Programmed Cell Death 1 Ligand 2 Protein programmed death ligand 2 Trypanosoma cruzi Trypanosoma cruzi - immunology
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