Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

Kruppel-like factor 4 (KLF4) is highly expressed in more than 70% of breast cancers and functions as an oncogene. However, an exact mechanism by which KLF4 enhances tumorigenesis of breast cancer remains unknown. In this study, we show that KLF4 was highly expressed in cancer stem cell (CSC)-enriche...

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Veröffentlicht in:	Oncogene 2011-05, Vol.30 (18), p.2161-2172
Hauptverfasser:	Yu, F, Li, J, Chen, H, Fu, J, Ray, S, Huang, S, Zheng, H, Ai, W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/395 631/67/71 631/80/84/2336 Aldehyde dehydrogenase Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - pathology Breast Neoplasms - physiopathology Cancer cells Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell physiology Cell surface Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colonies Development and progression Diabetes mellitus Fundamental and applied biological sciences. Psychology Gene expression Gene Knockdown Techniques Gynecology. Andrology. Obstetrics Health aspects Human Genetics Humans Internal Medicine KLF4 protein Krueppel-like factor Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - physiology Mammary gland Mammary gland diseases Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Neoplasm Invasiveness Neoplasm Metastasis Neoplastic Stem Cells - cytology Notch protein Oncogenes Oncology original-article Physiological aspects Progenitor cells Proteins Receptors, Notch - metabolism Risk factors Severe combined immunodeficiency Signal Transduction Stem cell transplantation Stem cells Surface markers Transcription factors Tumor cell lines Tumorigenesis Tumorigenicity Tumors
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