Pathbase: a database of mutant mouse pathology
Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain‐dependent backgr...
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| Veröffentlicht in: | Nucleic acids research 2004-01, Vol.32 (suppl-1), p.D512-D515 |
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| creator | Schofield, Paul N. Bard, Jonathan B. L. Booth, Catherine Boniver, Jacques Covelli, Vincenzo Delvenne, Philippe Ellender, Michele Engstrom, Wilhelm Goessner, Wolfgang Gruenberger, Michael Hoefler, Heinz Hopewell, John Mancuso, Mariatheresa Mothersill, Carmel Potten, Christopher S. Quintanilla‐Fend, Leticia Rozell, Bjorn Sariola, Hannu Sundberg, John P. Ward, Andrew |
| description | Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain‐dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high‐resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web‐based mouse genetic resources. |
| doi_str_mv | 10.1093/nar/gkh124 |
| format | Article |
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L. ; Booth, Catherine ; Boniver, Jacques ; Covelli, Vincenzo ; Delvenne, Philippe ; Ellender, Michele ; Engstrom, Wilhelm ; Goessner, Wolfgang ; Gruenberger, Michael ; Hoefler, Heinz ; Hopewell, John ; Mancuso, Mariatheresa ; Mothersill, Carmel ; Potten, Christopher S. ; Quintanilla‐Fend, Leticia ; Rozell, Bjorn ; Sariola, Hannu ; Sundberg, John P. ; Ward, Andrew</creator><creatorcontrib>Schofield, Paul N. ; Bard, Jonathan B. L. ; Booth, Catherine ; Boniver, Jacques ; Covelli, Vincenzo ; Delvenne, Philippe ; Ellender, Michele ; Engstrom, Wilhelm ; Goessner, Wolfgang ; Gruenberger, Michael ; Hoefler, Heinz ; Hopewell, John ; Mancuso, Mariatheresa ; Mothersill, Carmel ; Potten, Christopher S. ; Quintanilla‐Fend, Leticia ; Rozell, Bjorn ; Sariola, Hannu ; Sundberg, John P. ; Ward, Andrew</creatorcontrib><description>Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain‐dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high‐resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web‐based mouse genetic resources.</description><identifier>ISSN: 0305-1048</identifier><identifier>ISSN: 1362-4962</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/gkh124</identifier><identifier>PMID: 14681470</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Biochemistry, biophysics & molecular biology ; Biochimie, biophysique & biologie moléculaire ; Computational Biology ; Databases, Factual ; Disease ; Genotype ; Information Storage and Retrieval ; Internet ; Life sciences ; Mice ; Mutation ; Pathology ; Phenotype ; Sciences du vivant ; Vocabulary, Controlled</subject><ispartof>Nucleic acids research, 2004-01, Vol.32 (suppl-1), p.D512-D515</ispartof><rights>Copyright Oxford University Press(England) Jan 01, 2004</rights><rights>Copyright © 2004 Oxford University Press 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-b5a0f2435eb80dee9a907cee6aaac210eb2a67b413ac0c11ee6aae59aec2285a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC308858/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC308858/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14681470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schofield, Paul N.</creatorcontrib><creatorcontrib>Bard, Jonathan B. L.</creatorcontrib><creatorcontrib>Booth, Catherine</creatorcontrib><creatorcontrib>Boniver, Jacques</creatorcontrib><creatorcontrib>Covelli, Vincenzo</creatorcontrib><creatorcontrib>Delvenne, Philippe</creatorcontrib><creatorcontrib>Ellender, Michele</creatorcontrib><creatorcontrib>Engstrom, Wilhelm</creatorcontrib><creatorcontrib>Goessner, Wolfgang</creatorcontrib><creatorcontrib>Gruenberger, Michael</creatorcontrib><creatorcontrib>Hoefler, Heinz</creatorcontrib><creatorcontrib>Hopewell, John</creatorcontrib><creatorcontrib>Mancuso, Mariatheresa</creatorcontrib><creatorcontrib>Mothersill, Carmel</creatorcontrib><creatorcontrib>Potten, Christopher S.</creatorcontrib><creatorcontrib>Quintanilla‐Fend, Leticia</creatorcontrib><creatorcontrib>Rozell, Bjorn</creatorcontrib><creatorcontrib>Sariola, Hannu</creatorcontrib><creatorcontrib>Sundberg, John P.</creatorcontrib><creatorcontrib>Ward, Andrew</creatorcontrib><title>Pathbase: a database of mutant mouse pathology</title><title>Nucleic acids research</title><addtitle>Nucl. 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L.</au><au>Booth, Catherine</au><au>Boniver, Jacques</au><au>Covelli, Vincenzo</au><au>Delvenne, Philippe</au><au>Ellender, Michele</au><au>Engstrom, Wilhelm</au><au>Goessner, Wolfgang</au><au>Gruenberger, Michael</au><au>Hoefler, Heinz</au><au>Hopewell, John</au><au>Mancuso, Mariatheresa</au><au>Mothersill, Carmel</au><au>Potten, Christopher S.</au><au>Quintanilla‐Fend, Leticia</au><au>Rozell, Bjorn</au><au>Sariola, Hannu</au><au>Sundberg, John P.</au><au>Ward, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathbase: a database of mutant mouse pathology</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucl. Acids Res</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>32</volume><issue>suppl-1</issue><spage>D512</spage><epage>D515</epage><pages>D512-D515</pages><issn>0305-1048</issn><issn>1362-4962</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain‐dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. 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| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 2004-01, Vol.32 (suppl-1), p.D512-D515 |
| issn | 0305-1048 1362-4962 1362-4962 |
| language | eng |
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| source | Oxford Journals Open Access Collection; MEDLINE; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Computational Biology Databases, Factual Disease Genotype Information Storage and Retrieval Internet Life sciences Mice Mutation Pathology Phenotype Sciences du vivant Vocabulary, Controlled |
| title | Pathbase: a database of mutant mouse pathology |
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