Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin

Chitin is a skeletal cell wall polysaccharide of the inner cell wall of fungal pathogens. As yet, little about its role during fungus-host immune cell interactions is known. We show here that ultrapurified chitin from Candida albicans cell walls did not stimulate cytokine production directly but blo...

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Veröffentlicht in:	Infection and Immunity 2011-05, Vol.79 (5), p.1961-1970
Hauptverfasser:	Mora-Montes, Héctor M, Netea, Mihai G, Ferwerda, Gerben, Lenardon, Megan D, Brown, Gordon D, Mistry, Anita R, Kullberg, Bart Jan, O'Callaghan, Chris A, Sheth, Chirag C, Odds, Frank C, Brown, Alistair J.P, Munro, Carol A, Gow, Neil A.R, Deepe, G.S. Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Candida albicans Candida albicans - immunology Candidiasis - immunology cell walls chitin Chitin - immunology cytokines Cytokines - biosynthesis Cytokines - immunology Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections fungi Host-Parasite Interactions - immunology Humans Immunity, Innate - immunology innate immunity lectins Lectins, C-Type Leukocytes, Mononuclear - immunology lipopolysaccharides macrophages Macrophages - immunology Membrane Proteins - immunology Mice Mice, Inbred C57BL Mice, Knockout Microbiology Microscopy, Fluorescence Miscellaneous mononuclear leukocytes Mycology Nerve Tissue Proteins - immunology pathogens receptors
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