Adenovirus‐mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide‐induced acute lung injury in mice

Summary Acute lung injury is characterized by a diffuse inflammatory parenchymal process, implicated in the context of significant morbidity and mortality. Previously, we have reported that soluble ST2 (sST2), a member of the Toll‐interleukin (IL)‐1 receptor (TIR) superfamily, represses proinflammat...

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Veröffentlicht in:	Clinical and experimental immunology 2011-05, Vol.164 (2), p.248-255
Hauptverfasser:	Yin, H., Li, X. Y., Yuan, B. H., Zhang, B. B., Hu, S. L., Gu, H. B., Jin, X. B., Zhu, J. Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute Lung Injury - chemically induced Acute Lung Injury - complications Acute Lung Injury - pathology Acute Lung Injury - therapy adenoviral vector Adenoviridae - genetics Administration, Intranasal Analytical, structural and metabolic biochemistry Animal Models Animals Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Fundamental and applied biological sciences. Psychology Genetic Therapy Genetic Vectors - therapeutic use Hemorrhage - etiology Hemorrhage - prevention & control Immunologic Factors - genetics Immunologic Factors - physiology Immunologic Factors - therapeutic use inflammation Interleukin-1 Receptor-Like 1 Protein Interleukin-6 - biosynthesis Interleukin-6 - genetics Leukocytes - immunology Lipopolysaccharides - toxicity Male Mice Mice, Inbred BALB C NF-kappa B - metabolism NF‐κB Receptors, Interleukin - genetics Receptors, Interleukin - physiology Receptors, Interleukin - therapeutic use Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - physiology Recombinant Fusion Proteins - therapeutic use Solubility soluble ST2 Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - genetics Transgenes Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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