Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

The microvasculature assumes an inflammatory and procoagulant state in a variety of different diseases, including sickle cell disease (SCD), which may contribute to the high incidence of ischemic stroke in these patients. This study provides evidence for accelerated thrombus formation in arterioles...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2011-04, Vol.117 (15), p.4125-4133
Hauptverfasser:	Gavins, Felicity N.E., Russell, Janice, Senchenkova, Elena L., De Almeida Paula, Lidiana, Damazo, Amílcar S., Esmon, Charles T., Kirchhofer, Daniel, Hebbel, Robert P., Granger, D. Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - complications Anemia, Sickle Cell - genetics Anemia, Sickle Cell - metabolism Animals Biological and medical sciences Blood Platelets - metabolism Bone Marrow Transplantation Cerebral Arteries - metabolism Disease Models, Animal Hematologic and hematopoietic diseases Hemoglobin, Sickle - genetics Hemoglobin, Sickle - metabolism Intracranial Thrombosis - etiology Intracranial Thrombosis - genetics Intracranial Thrombosis - metabolism Male Medical sciences Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Inbred DBA Mice, Mutant Strains Microcirculation - physiology Neutrophils - metabolism Platelet Aggregation - physiology Protein C - metabolism Red Cells, Iron, and Erythropoiesis Thrombin - metabolism Thromboplastin - metabolism Thrombosis and Hemostasis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!