Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

Activation of the complement cascade induces inflammatory responses and marks cells for immune clearance. In the central complement-amplification step, a complex consisting of surface-bound C3b and factor B is cleaved by factor D to generate active convertases on targeted surfaces. We present crysta...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2010-12, Vol.330 (6012), p.1816-1820
Hauptverfasser:	Forneris, Federico, Ricklin, Daniel, Wu, Jin, Tzekou, Apostolia, Wallace, Rachel S, Lambris, John D, Gros, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Active sites Amplification Binding Binding Sites Biochemistry Biological and medical sciences Cartoons Cascades Catalysis Catalytic Domain Complement Complement C3 Convertase, Alternative Pathway - chemistry Complement C3 Convertase, Alternative Pathway - metabolism Complement C3b - chemistry Complement C3b - metabolism Complement Factor B - chemistry Complement Factor B - metabolism Complement Factor D - chemistry Complement Factor D - metabolism Complement Pathway, Alternative Crystal structure Crystallography, X-Ray Displacement Electronic structure Enzymes Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune system Models, Molecular Molecular immunology Mutant Proteins - chemistry Protein Binding Protein Conformation Protein Structure, Tertiary Rotation Substrate specificity Surface chemistry
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