Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women
Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire, and Wisconsin to examine six strategically selected C...
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| Veröffentlicht in: | Anticancer research 2010-01, Vol.30 (1), p.217-220 |
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| creator | PETERSON, Neeraja B TRENTHAM-DIETZ, Amy GARCIA-CLOSAS, Montserrat NEWCOMB, Polly A TITUS-ERNSTOFF, Linda YIFAN HUANG CHANOCK, Stephen J HAINES, Jonathan L EGAN, Kathleen M |
| description | Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene
could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire,
and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including
the val158met polymorphism (rs4680), in relation to breast cancer risk. Analyses were based on 1,655 Caucasian women with
invasive breast cancer and 1,470 Caucasian controls. None of the six individual SNPs were associated with breast cancer risk.
The global test for haplotype associations was nonsignificant (p-value=0.097), although two uncommon haplotypes present in
6% of the study population showed statistically significant inverse associations with risk. These results suggest that genetic
variation in COMT has no significant association with breast cancer risk among Caucasian women. |
| format | Article |
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could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire,
and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including
the val158met polymorphism (rs4680), in relation to breast cancer risk. Analyses were based on 1,655 Caucasian women with
invasive breast cancer and 1,470 Caucasian controls. None of the six individual SNPs were associated with breast cancer risk.
The global test for haplotype associations was nonsignificant (p-value=0.097), although two uncommon haplotypes present in
6% of the study population showed statistically significant inverse associations with risk. These results suggest that genetic
variation in COMT has no significant association with breast cancer risk among Caucasian women.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 20150638</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast Neoplasms - enzymology ; Breast Neoplasms - genetics ; Case-Control Studies ; Catechol O-Methyltransferase - genetics ; European Continental Ancestry Group - genetics ; Female ; Genetic Predisposition to Disease ; Gynecology. Andrology. Obstetrics ; Haplotypes ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide ; Tumors ; Young Adult</subject><ispartof>Anticancer research, 2010-01, Vol.30 (1), p.217-220</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,4009</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22389749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20150638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PETERSON, Neeraja B</creatorcontrib><creatorcontrib>TRENTHAM-DIETZ, Amy</creatorcontrib><creatorcontrib>GARCIA-CLOSAS, Montserrat</creatorcontrib><creatorcontrib>NEWCOMB, Polly A</creatorcontrib><creatorcontrib>TITUS-ERNSTOFF, Linda</creatorcontrib><creatorcontrib>YIFAN HUANG</creatorcontrib><creatorcontrib>CHANOCK, Stephen J</creatorcontrib><creatorcontrib>HAINES, Jonathan L</creatorcontrib><creatorcontrib>EGAN, Kathleen M</creatorcontrib><title>Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene
could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire,
and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including
the val158met polymorphism (rs4680), in relation to breast cancer risk. Analyses were based on 1,655 Caucasian women with
invasive breast cancer and 1,470 Caucasian controls. None of the six individual SNPs were associated with breast cancer risk.
The global test for haplotype associations was nonsignificant (p-value=0.097), although two uncommon haplotypes present in
6% of the study population showed statistically significant inverse associations with risk. These results suggest that genetic
variation in COMT has no significant association with breast cancer risk among Caucasian women.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - enzymology</subject><subject>Breast Neoplasms - genetics</subject><subject>Case-Control Studies</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1LwzAUhosobk7_guRC8aqQ9LRNeiPMoU6YCKJ4GU7TxEXbZCad4r-3sPl1dXg5D88L704yZrxiKS-A7iZjmhU05ZQWo-QgxhdKy7ISsJ-MMsoKWoIYJ_NpjF5Z7K13xBsyu7t9IHNctb7_XOlI0DXkImiMPZmhUzqQextfiXVDXCuMFh158p12h8mewTbqo-2dJI9Xlw-zebq4u76ZTRfpErK8T5FxAwI0A2O4YDQvaqhNhg3XooEKM2WEElpxMEzkTW3KvDGlqbipGaOGwyQ533hX67rTjdKuD9jKVbAdhk_p0cr_H2eX8tm_S6Ci5LkYBGdbQfBvax172dmodNui034dJQfgrBAFHcjjv1U_Hd_rDcDpFsCosDVhWMjGXy4DUfG8GriTDbe0z8sPG7SMHbbtoAWJAahkMmMcvgDQCoaP</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>PETERSON, Neeraja B</creator><creator>TRENTHAM-DIETZ, Amy</creator><creator>GARCIA-CLOSAS, Montserrat</creator><creator>NEWCOMB, Polly A</creator><creator>TITUS-ERNSTOFF, Linda</creator><creator>YIFAN HUANG</creator><creator>CHANOCK, Stephen J</creator><creator>HAINES, Jonathan L</creator><creator>EGAN, Kathleen M</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100101</creationdate><title>Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women</title><author>PETERSON, Neeraja B ; TRENTHAM-DIETZ, Amy ; GARCIA-CLOSAS, Montserrat ; NEWCOMB, Polly A ; TITUS-ERNSTOFF, Linda ; YIFAN HUANG ; CHANOCK, Stephen J ; HAINES, Jonathan L ; EGAN, Kathleen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h324t-a17f383e13ff781045b3bf2ad7e8d39a2cf8c8ec73f184dbf64df6f97fb110f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - enzymology</topic><topic>Breast Neoplasms - genetics</topic><topic>Case-Control Studies</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PETERSON, Neeraja B</creatorcontrib><creatorcontrib>TRENTHAM-DIETZ, Amy</creatorcontrib><creatorcontrib>GARCIA-CLOSAS, Montserrat</creatorcontrib><creatorcontrib>NEWCOMB, Polly A</creatorcontrib><creatorcontrib>TITUS-ERNSTOFF, Linda</creatorcontrib><creatorcontrib>YIFAN HUANG</creatorcontrib><creatorcontrib>CHANOCK, Stephen J</creatorcontrib><creatorcontrib>HAINES, Jonathan L</creatorcontrib><creatorcontrib>EGAN, Kathleen M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PETERSON, Neeraja B</au><au>TRENTHAM-DIETZ, Amy</au><au>GARCIA-CLOSAS, Montserrat</au><au>NEWCOMB, Polly A</au><au>TITUS-ERNSTOFF, Linda</au><au>YIFAN HUANG</au><au>CHANOCK, Stephen J</au><au>HAINES, Jonathan L</au><au>EGAN, Kathleen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>30</volume><issue>1</issue><spage>217</spage><epage>220</epage><pages>217-220</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene
could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire,
and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including
the val158met polymorphism (rs4680), in relation to breast cancer risk. Analyses were based on 1,655 Caucasian women with
invasive breast cancer and 1,470 Caucasian controls. None of the six individual SNPs were associated with breast cancer risk.
The global test for haplotype associations was nonsignificant (p-value=0.097), although two uncommon haplotypes present in
6% of the study population showed statistically significant inverse associations with risk. These results suggest that genetic
variation in COMT has no significant association with breast cancer risk among Caucasian women.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>20150638</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Breast Neoplasms - enzymology Breast Neoplasms - genetics Case-Control Studies Catechol O-Methyltransferase - genetics European Continental Ancestry Group - genetics Female Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics Haplotypes Humans Mammary gland diseases Medical sciences Middle Aged Polymorphism, Single Nucleotide Tumors Young Adult |
| title | Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women |
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