A Modular System for the Synthesis of Multiplexed Magnetic Resonance Probes

We have developed a modular architecture for preparing high-relaxivity multiplexed probes utilizing click chemistry. Our system incorporates azide bearing Gd(III) chelates and a trialkyne scaffold with a functional group for subsequent modification. In optimizing the relaxivity of this new complex,...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-04, Vol.133 (14), p.5329-5337
Hauptverfasser:	Mastarone, Daniel J, Harrison, Victoria S. R, Eckermann, Amanda L, Parigi, Giacomo, Luchinat, Claudio, Meade, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Azides - chemistry Chelating Agents - chemistry Click Chemistry Contrast Media - chemical synthesis Contrast Media - chemistry Drug Design Gadolinium - chemistry Magnetic Resonance Imaging Models, Molecular Molecular Conformation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Temperature
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