Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis

Immune activation of fibrosis likely has a crucial role in the pathogenesis of systemic sclerosis (SSc). The aim of this study was to better understand the innate immune regulation and associated IFN- and transforming growth factor-β (TGFβ)-responsive gene expression in SSc skin and dermal fibroblas...

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Veröffentlicht in:	Journal of investigative dermatology 2010-11, Vol.130 (11), p.2583-2593
Hauptverfasser:	Farina, Giuseppina A., York, Michael R., Di Marzio, Michael, Collins, Cindy A., Meller, Stephan, Homey, Bernhard, Rifkin, Ian R., Marshak-Rothstein, Ann, Radstake, Timothy R.D.J., Lafyatis, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Cells, Cultured Dermatitis - genetics Dermatitis - immunology Dermatitis - pathology Dermis - immunology Dermis - pathology Disease Models, Animal Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - immunology Gene Expression - immunology GTP-Binding Proteins - metabolism Humans Interferon Type I - immunology Interferon Type I - metabolism Interferon-gamma - immunology Interferon-gamma - metabolism Lupus Erythematosus, Cutaneous - genetics Lupus Erythematosus, Cutaneous - immunology Lupus Erythematosus, Cutaneous - pathology Mice Mice, Inbred C57BL Mice, Mutant Strains Myxovirus Resistance Proteins Poly I-C - metabolism Poly I-C - pharmacology Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Scleroderma, Systemic - pathology Toll-Like Receptor 3 - agonists Toll-Like Receptor 3 - immunology Toll-Like Receptor 3 - metabolism Transforming Growth Factor beta - immunology Transforming Growth Factor beta - metabolism
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