Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

The mitochondrial protein apoptosis-inducing factor (AIF) plays a pivotal role in poly(ADP-ribose) polymerase-1 (PARP-1)-mediated cell death (parthanatos), during which it is released from the mitochondria and translocates to the nucleus. We show that AIF is a high-affinity poly(ADP-ribose) (PAR)-bi...

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Veröffentlicht in:	Science signaling 2011-04, Vol.4 (167), p.ra20-ra20
Hauptverfasser:	Wang, Yingfei, Kim, No Soo, Haince, Jean-Francois, Kang, Ho Chul, David, Karen K, Andrabi, Shaida A, Poirier, Guy G, Dawson, Valina L, Dawson, Ted M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis of Variance Animals Apoptosis Inducing Factor - chemistry Apoptosis Inducing Factor - genetics Apoptosis Inducing Factor - metabolism Arginine - metabolism Base Sequence Cell Death - physiology Electrophoretic Mobility Shift Assay Genetic Vectors - genetics Immunoblotting Immunohistochemistry Immunoprecipitation Lentivirus Lysine - metabolism Mice Models, Molecular Molecular Sequence Data Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Polymerases - metabolism Sequence Analysis, DNA Transfection
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