RSV-Induced Bronchial Epithelial Cell PD-L1 Expression Inhibits CD8⁺ T Cell Nonspecific Antiviral Activity

Respiratory syncytial virus (RSV) is a major cause of bronchiolitis in infants. It is also responsible for high morbidity and mortality in the elderly. Programmed death ligands (PD-Ls) on antigen-presenting cells interact with receptors on T cells to regulate immune responses. The programmed death r...

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Veröffentlicht in:	The Journal of infectious diseases 2011-01, Vol.203 (1), p.85-94
Hauptverfasser:	Telcian, Aurica G., Laza-Stanca, Vasile, Edwards, Michael R., Harker, James A., Wang, Hongwei, Bartlett, Nathan W., Mallia, Patrick, Zdrenghea, Mihnea T., Kebadze, Tatiana, Coyle, Anthony J., Openshaw, Peter J.M., Stanciu, Luminita A., Johnston, Sebastian L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antivirals Apoptosis B7-H1 Antigen Biological and medical sciences CD8-Positive T-Lymphocytes - immunology Cell lines Cells, Cultured Coculture Techniques Cytokines Epithelial cells Epithelial Cells - virology Fundamental and applied biological sciences. Psychology Human respiratory syncytial virus Humans Immune Tolerance Infections Infectious diseases Major and Brief Reports Medical sciences Memory Microbiology Respiratory syncytial virus infections Respiratory Syncytial Viruses - immunology Respiratory Syncytial Viruses - pathogenicity Viruses
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